ERCC2 /XPD Gene Polymorphisms and Lung Cancer: A HuGE Review
نویسندگان
چکیده
منابع مشابه
ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.
The xeroderma pigmentosum group D (XPD) protein is a well-characterized DNA helicase necessary for the nucleotide excision repair of bulky DNA lesions, such as those induced by cigarette smoking. Polymorphisms in several exons of the XPD gene have been identified; two of them, Asp312Asn and Lys751Gln, are common and result in an amino acid change. Most of the reported data indicate higher level...
متن کاملXRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review.
Hundreds of polymorphisms in DNA repair genes have been identified; however, for many of these polymorphisms, the impact on repair phenotype and cancer susceptibility remains uncertain. In this review, the authors focused on the x-ray repair cross-complementing protein group 3 (XRCC3) and xeroderma pigmentosum group D (XPD)/excision repair cross-complementing rodent repair deficiency (ERCC2) ge...
متن کاملThe Effect of XPD/ERCC2 Polymorphisms on Gastric Cancer Risk among Different Ethnicities: A Systematic Review and Meta-Analysis
BACKGROUND Potential xeroderma pigmentosum group D (XPD), also called excision repair cross-complimentary group two (ERCC2), Lys751Gln and Asp312Asn polymorphisms have been implicated in gastric cancer risk among different ethnicities. METHODS We aimed to explore the effect of XPD Lys751Gln and Asp312Asn polymorphisms on the susceptibility to gastric cancer among different ethnicities through...
متن کاملPolymorphisms in the nuclear excision repair gene ERCC2/XPD and susceptibility to cutaneous basal cell carcinoma.
Studies have investigated the relationship between XPD Lys751Gln and Asp312Asn genetic variants and risk of cutaneous basal cell carcinoma (BCC). However, the results remain inconclusive. We performed a meta-analysis, using a comprehensive strategy based on the allele model and a model-free approach, to investigate the association of between XPD Lys751Gln and Asp312Asn polymorphisms with BCC ri...
متن کاملDNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population.
X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) are mainly involved in base excision repair (BER) and nucleotide excision repair (NER) of DNA repair pathways, respectively. Polymorphisms of DNA repair gene XRCC1 and XPD has recently been identified, and there is a growing body of evidence that these polymorphisms may have some phenotypic significance. To...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2005
ISSN: 0002-9262
DOI: 10.1093/aje/kwi018